A Mitochondrial Expatriate: Nuclear Pyruvate Dehydrogenase
نویسندگان
چکیده
The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate into acetyl-CoA, a critical step in metabolism. Sutendra et al. now demonstrate that PDC can translocate from the mitochondria to the nucleus to provide acetyl-CoA necessary for histone acetylation, suggesting a new pathway for mitochondrial-nuclear communication.
منابع مشابه
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عنوان ژورنال:
- Cell
دوره 158 شماره
صفحات -
تاریخ انتشار 2014